CUG-BP-& ETR-3-like factor 6 (CELF-6, Bruno-like protein 6, RNA-binding protein BRUNOL-6, BRUNOL6, CELF6)

Function

• RNA-binding protein
• role in regulation of pre- mRNA alternative splicing
• mediates exon inclusion &/or exclusion in pre-mRNA subject to tissue-specific & developmentally regulated alternative splicing
• specifically activates exon 5 inclusion of TNNT2 (muscle-specific)
• promotes also exon exclusion of INSR pre-mRNA

Structure

• belongs to the CELF/BRUNOL family
• contains 3 RRM (RNA recognition motif) domains

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed mainly in kidney, brain, testis
• present in other tissues at lower levels.
• expressed in fetal kidney

More general terms

• CUG-BP- & ETR-3-like factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q96J87.html