otopetrin-1 (OTOP1)

Function

• required for normal formation of otoconia in the inner ear
• inhibits P2Y purinoceptors
• modulates Ca+2 homeostasis & influx of Ca+2 in response to extracellular ATP

Structure

belongs to the otopetrin family

Compartment

• membrane, secreted, extracellular space
• detected in the gelatinous membrane overlying the inner ear macular epithelium

More general terms

• otopetrin (OTOP)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1330
• OMIM: https://mirror.omim.org/entry/607806
• UniProt: http://www.uniprot.org/uniprot/Q7RTM1.html