polypeptide N-acetylgalactosaminyltransferase 2; protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; polypeptide GalNAc transferase 2; GalNAc-T2; pp-GaNTase 2 [Contains: polypeptide N-acetylgalactosaminyltransferase 2 soluble form] (GALNT2)
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Function
- glycoprotein synthesis
- catalyzes initial reaction in O-linked oligosaccharide biosynthesis, transfer of an N-acetyl-D-galactosamine residue to Ser or Thr on nascent protein
- broad spectrum of substrates for peptides including: EA2, Muc5AC, Muc1a, Muc1b
- role in O-linked glycosylation of IgA1 hinge region
- ricin B-type lectin domain binds to GalNAc & contributes to glycopeptide specificity
UDP-N-acetyl-D-galactosamine + polypeptide <--> UDP + N-acetyl-D-galactosaminyl-polypeptide
Structure
- belongs to the glycosyltransferase 2 family. GalNAc-T subfamily
- contains 1 ricin B-type lectin domain
- 2 conserved domains in the glycosyltransferase region:
Compartment
Expression
widely expressed
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q10471.html
- ↑ GGDB, GlycoGene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp