neuroligin-4, X-linked; neuroligin X; HNLX (NLGN4X, KIAA1260, NLGN4, UNQ365/PRO701)

Function

• putative neuronal cell surface protein involved in cell-cell-interactions
• interacts through its C-terminus with DLG4/PSD-95 3rd PDZ domain

Structure

• belongs to the type-B carboxylesterase/lipase family

Compartment

• membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

• expressed at highest levels in heart
• expressed at lower levels in liver, skeletal muscle & pancreas
• expressed at very low levels in brain

Pathology

• defects in NLGN4X may be the cause
  • susceptibility to autism X-linked type 2
  • susceptibility to X-linked Asperger syndrome 2

More general terms

• neuroligin

Additional terms

• Asperger syndrome
• autism (autistic spectrum disorder, ASD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57502
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57502
• OMIM: https://mirror.omim.org/entry/300427
• OMIM: https://mirror.omim.org/entry/300495
• OMIM: https://mirror.omim.org/entry/300497
• UniProt: http://www.uniprot.org/uniprot/Q8N0W4.html