signal peptide peptidase-like 2B; SPP-like 2B; SPPL2b; intramembrane protease 4; IMP-4; presenilin-like protein 1 (SPPL2B, IMP4, KIAA1532, PSL1)

Function

• intramembrane protease
• role in ITM2B processing
• interacts with ITM2B

Structure

• belongs to the peptidase A22B family
• contains 1 PA (protease associated) domain

Compartment

• Golgi membrane; multi-pass membrane protein

Alternative splicing

named isoforms=4

More general terms

• presenilin-like protein
• transmembrane 7 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56928
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56928
• OMIM: https://mirror.omim.org/entry/608239
• UniProt: http://www.uniprot.org/uniprot/Q8TCT7.html