junctophilin-1; JP-1; junctophilin type 1 (JPH1, JP1)

Function

• contributes to stabilization of junctional membrane complexes, common to excitable cells
• probably acts by anchoring the plasma membrane & endoplasmic/sarcoplasmic reticulum
• contributes to the construction of skeletal muscle triad junctions (putative)

Structure

• the MORN (membrane occupation & recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (putative)
• belongs to the junctophilin family
• contains 7 MORN repeats

Compartment

• cell membrane; peripheral membrane protein (putative)
• single-pass type 4 membrane protein (putative)
• endoplasmic reticulum (ER) membrane
• sarcoplasmic reticulum (SR) membrane
• localized predominantly on the plasma membrane
• the transmembrane domain is anchored in ER/SR membrane
• the N-terminal part associates with the plasma membrane
• in skeletal muscle cells, it is predominantly localized at the junction of the A & I bands (putative)

Expression

specifically expressed in skeletal muscle

More general terms

• junctophilin
• phosphoprotein

Component of

• triad junction (junctional membrane complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56704
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56704
• OMIM: https://mirror.omim.org/entry/605266
• UniProt: http://www.uniprot.org/uniprot/Q9HDC5.html