synaptogyrin-3 (SYNGR3)

Function

• role in positive regulation of dopamine transporter activity
• probably facilitates physical & functional interactions of the dopamine transporter with the dopamine vesicular storage system, allowing a more efficient loading of vesicles with extracellular dopamine after release
• interacts (via N-terminus) with SLC6A3 (via N-terminus)

Structure

• belongs to the synaptogyrin family
• contains 1 MARVEL domain

Compartment

• membrane
• cytoplasmic vesicle, secretory vesicle, synaptic vesicle
• cell junction, synapse
• found at neuromuscular synapses (putative)

Expression

expressed in brain & placenta

More general terms

• synaptogyrin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9143
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9143
• OMIM: https://mirror.omim.org/entry/603927
• UniProt: http://www.uniprot.org/uniprot/O43761.html