peroxisome assembly protein 26; peroxin-26 (PEX26)
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Function
- probably required for protein import into peroxisomes
- anchors PEX1 & PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
- involved in the import of catalase & proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence
- interacts directly with PEX6 via its cytoplasmic domain
- interacts indirectly with PEX1, via its interaction with PEX6
Structure
belongs to the peroxin-26 family
Compartment
- peroxisome membrane; single-pass type 2 membrane protein
Expression
-widely expressed
- highly expressed in kidney, liver, brain & skeletal muscles
- expressed at intermediate level in pancreas, placenta & heart
- weakly expressed in lung
Pathology
- defects in PEX26 are the cause of peroxisome biogenesis disorder complementation group 8
- defects in PEX26 are a cause of
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q7Z412.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=PEX26
- ↑ dbPEX, PEX gene Database http://www.dbpex.org/home.php?select_db=PEX26
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55670
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55670
- OMIM: https://mirror.omim.org/entry/202370
- OMIM: https://mirror.omim.org/entry/214100
- OMIM: https://mirror.omim.org/entry/266510
- OMIM: https://mirror.omim.org/entry/601539
- OMIM: https://mirror.omim.org/entry/608666
- UniProt: http://www.uniprot.org/uniprot/Q7Z412.html