peroxisomal membrane protein PEX14; peroxisomal membrane anchor protein PEX14; peroxin-14; PTS1 receptor-docking protein (PEX14)

Function

• component of the peroxisomal translocation machinery with PEX13 & PEX17
• interacts with both the PTS1 & PTS2 receptors
• binds directly to PEX17
• interacts with PEX5 & PEX19

Structure

belongs to the peroxin-14 family

Compartment

• peroxisome membrane
• peripheral membrane protein; cytoplasmic side

Alternative splicing

named isoforms=2

Pathology

• defects in PEX14 are the cause of peroxisome biogenesis disorder complementation group K
• defects in PEX14 are a cause of Zellweger syndrome

More general terms

• peroxisomal membrane protein (peroxin)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5195
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5195
• OMIM: https://mirror.omim.org/entry/214100
• OMIM: https://mirror.omim.org/entry/601791
• UniProt: http://www.uniprot.org/uniprot/O75381.html