peroxisomal membrane protein PEX13; peroxin-13 (PEX13)

Function

• component of the peroxisomal translocation machinery with PEX14 & PEX17
• functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5)
• involved in import of PTS1 & PTS2 proteins
• interacts with PEX19

Structure

• belongs to the peroxin-13 family
• contains 1 SH3 domain

Compartment

peroxisome membrane; single-pass membrane protein

Pathology

• defects in PEX13 are the cause of peroxisome biogenesis disorder complementation group 13
• defects in PEX13 are a cause of neonatal adrenoleukodystrophy

More general terms

• peroxisomal membrane protein (peroxin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5194
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5194
• OMIM: https://mirror.omim.org/entry/202370
• OMIM: https://mirror.omim.org/entry/601789
• UniProt: http://www.uniprot.org/uniprot/Q92968.html