UDP-glucuronosyltransferase-1F (phenol-metabolizing UDP-glucuronosyltransferase, UGT1A6, GNT1, UGT1UDPGT-1F)

Function

• UDPGT is of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
• specificity for phenols

UDP-glucuronate + acceptor
              <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome, endoplasmic reticulum

Alternative splicing

• named isoforms=1
• a number of isoforms may be produced
• different isoforms have a different N-terminal domain & a common C-terminal domain of 245 residues

Expression

expressed in skin, kidney & liver

Polymorphism

• polymorphisms in UGT1A6 gene define 4 common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 & UGT1A6*4
• liver tissue samples homozygous for UGT1A6*2 exhibited a high rate of glucuronidation relative to tissues with other genotypes
• common genetic variation in UGT1A6 confers functionally significant differences in biochemical phenotype
• polymorphism might impact clinical efficacy or toxicity of drugs metabolized by UGT1A6

More general terms

• UDP-glucuronosyltransferase-1 (UDPGT-1)

Database

• UniProt: http://www.uniprot.org/uniprot/P19224.html
• OMIM: https://mirror.omim.org/entry/191740
• OMIM: https://mirror.omim.org/entry/606431