Outer dense fiber protein 2 (outer dense fiber of sperm tails protein 2, cenexin, ODF2)

Function

• seems to be a major component of sperm tail outer dense fibers
• may have a modulating influence on sperm motility
• functions as general scaffold protein specifically localized at the distal/subdistal appendages of mother centrioles
• component of the centrosome matrix
• required for the localization of PLK1 & NIN to centrosomes
• required for the formation &/or maintenance of normal CETN1 assembly
• self-associates
• associates with microtubules & forms a fibrillar structure partially linked to the microtubule network
• interacts via its C-terminus with PLK1
• interacts with ODF1

Structure

belongs to the ODF2 family

Compartment

• centrosome
• localized at the microtubule organizing centers in interphase & spindle poles in mitosis
• localized at the distal/subdistal appendages of mother centrioles

Alternative splicing

named isoforms=6

Expression

• testis-specific (at protein level)
• highly expressed in cytoplasm of step 2 round spermatids
• detected in the middle piece & extends to about half the principal piece of the sperm tails

More general terms

• outer dense fiber protein (ODF1, ODFP)
• scaffold protein

Database

• OMIM: https://mirror.omim.org/entry/602015
• UniProt: http://www.uniprot.org/uniprot/Q5BJF6.html