glycerol-3-phosphate acyltransferase, mitochondrial (GPAT, GPAM, KIAA1560)

Function

• de novo phospholipid biosynthesis, 1st step

Acyl-CoA + sn-glycerol 3-phosphate

<-->

CoA + 1-acyl-sn-glycerol 3-phosphate

Structure

• belongs to the GPAT/DAPAT family
• HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for phosphate moiety of glycerol-3-phosphate

Compartment

mitochondrial outer membrane

More general terms

• acyltransferase
• mitochondrial membrane protein

Database

• OMIM: https://mirror.omim.org/entry/602395
• UniProt: http://www.uniprot.org/uniprot/Q9HCL2.html