hepatocellular carcinoma-down-regulated mitochondrial carrier protein; solute carrier family 25 member 47 (SLC25A47, C14orf68, HDMCP, HMFN1655)

Function

• uncoupling protein
• may catalyze the physiological 'proton leak' in liver mitochondrial electron transport
• overexpression induces dissipation of mitochondrial membrane potential

Structure

• belongs to the mitochondrial carrier family
  • contains 3 Solcar repeats

Compartment

mitochondrial inner membrane

Alternative splicing

named isoforms=2

Expression

specifically expressed in liver

Pathology

down-regulated in hepatocarcinoma

More general terms

• mitochondrial membrane protein
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=283600
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:283600
• OMIM: https://mirror.omim.org/entry/609911
• UniProt: http://www.uniprot.org/uniprot/Q6Q0C1.html