NADP+ transhydrogenase mitochondrial; pyridine nucleotide transhydrogenase, nicotinamide nucleotide transhydrogenase (NNT)

Function

• transhydrogenation between NADH & NADP+ is coupled to respiration & ATP hydrolysis & functions as a proton pump across the inner mitochondrial membrane.

                NNT
NADPH + NAD+    <--->   NADP+ + NADH

Structure

homodimer

Compartment

mitochondrial inner membrane, matrix side

More general terms

• dehydrogenase
• mitochondrial membrane protein
• transmembrane 14e protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23530
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23530
• OMIM: https://mirror.omim.org/entry/607878
• UniProt: http://www.uniprot.org/uniprot/Q13423.html