steroidogenic acute regulatory protein, mitochondrial; StAR; StARD1 (STAR)
Jump to navigation
Jump to search
Function
- role in movement of cholesterol across the outer mitochondrial membrane in steroidogenic cells for delivery to cyt P450scc (cholesterol 20,22 desmolase) within the inner mitochondrial membrane
- role in steroid hormone synthesis by enhancing metabolism of cholesterol into pregnenolone
- mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone
- steroid metabolism; cholesterol metabolism
- may interact with TSPO (putative)
Structure
contains 1 START domain
Compartment
Expression
- expressed in gonads, adrenal cortex & kidney
Pathology
- defects in STAR are a cause of adrenal hyperplasia 1
More general terms
References
- ↑ Waterman MR. A rising StAR: an essential role in cholesterol transport. Science. 1995 Mar 24;267(5205):1780-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7892600
- ↑ Lin D, Sugawara T, Strauss JF 3rd, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science. 1995 Mar 24;267(5205):1828-31. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7892608
- ↑ UniProt http://www.uniprot.org/uniprot/P49675.html
- ↑ Wikipedia; steroidogenic acute regulatory protein entry http://en.wikipedia.org/wiki/steroidogenic_acute_regulatory_protein
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=STAR