amiloride-sensitive Na+ channel subunit gamma; epithelial Na+ channel subunit gamma; gamma-ENaC; SCNEG; nonvoltage-gated Na+ channel 1 subunit gamma; gamma-NaCH (SCNN1G)

Function

• Na+ permeable non-voltage-sensitive ion channel gamma subunit
• phosphorylated on Ser & Thr
• ubiquitination targets individual subnits for endocytosis & proteasome-mediated degradation (putative)
• interacts with the WW domains of NEDD4, NEDD4L, WWP1 & WWP2

Structure

• belongs to the amiloride-sensitive Na+ channel family

Compartment

• apical cell membrane; multi-pass membrane protein
• apical membrane of epithelial cells

Pathology

• defects in SCNN1G are a cause of Liddle syndrome

More general terms

• transmembrane 2 protein
• amiloride sensitive Na+ channel subunit

Component of

• amiloride-sensitive Na+ channel or lung Na+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6340
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6340
• OMIM: https://mirror.omim.org/entry/177200
• OMIM: https://mirror.omim.org/entry/600761
• UniProt: http://www.uniprot.org/uniprot/P51170.html