protocadherin-12; vascular cadherin-2; vascular endothelial cadherin-2; VE-cadherin-2; VE-cad-2 (PCDH12)

Function

• cellular adhesion molecule
• may play a role in cell-cell interactions at inter-endothelial junctions
• promotes homotypic Ca+2 dependent aggregation & adhesion &
• clusters at intercellular junctions
• anable to bind to catenins
• weakly associates with the cytoskeleton (putative)

Structure

contains 6 cadherin domains

Compartment

• cell membrane, cell junction
• single-pass type 1 membrane protein

Expression

• expressed in highly vascularized tissues including heart & placenta
• low expression in most tissues
• prominent expression in spleen

More general terms

• protocadherin (PCDH)

Additional terms

• CD144 (cadherin-5, vascular endothelial cadherin, VE-cadherin, 74B antigen, CDH5)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51294
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51294
• OMIM: https://mirror.omim.org/entry/605622
• UniProt: http://www.uniprot.org/uniprot/Q9NPG4.html