Mas-related G protein-coupled receptor member X1 (sensory neuron-specific G-protein coupled receptor 2, MRGPRX1, MRGX1, SNSR4)

Function

• orphan receptor
• nociceptor function &/or development (putative)
  • sensation or modulation of pain
  • activated by enkephalins, including BAM22 (bovine adrenal medulla peptide 22)
• Gq proteins transduce signal (putative)

Structure

• belongs to the G-protein coupled receptor 1 family mas subfamily

Compartment

• cell membrane
• uniquely expressed in a subset of small dorsal root ganglion & trigeminal sensory neurons

More general terms

• mas-related G protein coupled receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2592
• OMIM: https://mirror.omim.org/entry/607227
• UniProt: http://www.uniprot.org/uniprot/Q96LB2.html