Mas-related G protein-coupled receptor member D (beta-alanine receptor, G-protein coupled receptor TGR7,MRGPRD MRGD)

Function

• regulation of nociceptor function &/or development
• sensation or modulation of pain
• specific membrane receptor for beta-alanine
  • beta-alanine at micromolar doses evokes Ca+2 influx in cells expressing MRGPRD
• receptor couples with G-protein Gq & Gi

Structure

• belongs to the G-protein coupled receptor 1 family mas subfamily

Compartment

• plasma membrane
• internalized with binding of beta-alanine

More general terms

• mas-related G protein coupled receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1165
• OMIM: https://mirror.omim.org/entry/607231
• UniProt: http://www.uniprot.org/uniprot/Q8TDS7.html