Na+/glucose cotransporter 2; Na+/glucose cotransporter like; low affinity Na+ glucose cotransporter; solute carrier family 5 member 2 (SLC5A2, SGLT2)

Function

• Na+ dependent glucose transporter
• has a Na+ to glucose coupling ratio of 1:1
• efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity & a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules

Structure

• belongs to the Na+:solute symporter (SSF) (TC 2.A.21) family

Compartment

membrane

Pathology

• defects in SLC5A2 are the cause of renal glucosuria

Pharmacology

• SGLT2 inhibitors for treatment of diabetes mellitus type-2

More general terms

• transmembrane 11 protein
• glucose transporter

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6524
• OMIM: https://mirror.omim.org/entry/182381
• OMIM: https://mirror.omim.org/entry/233100
• UniProt: http://www.uniprot.org/uniprot/P31639.html