vasopressin V2 receptor; AVPR V2; renal-type arginine vasopressin receptor; antidiuretic hormone receptor (AVPR2 ADHR DIR DIR3 V2R)
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Function
- receptor for arginine vasopressin
- activity is mediated by G proteins which activate
- exerts antidiuretic effect in kidney
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Expression
kidney
Pathology
- gain of function mutations in AVPR2 may be associated with syndrome of antidiuretic hormone secretion (SIADH)
- defects in AVPR2 are a cause
- of X-linked nephrogenic diabetes insipidus, type 1
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P30518.html
- ↑ nephrogenic & neurogenic diabetes insipidus: AVPR2 pages http://www.medicine.mcgill.ca/nephros/avpr2.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=AVPR2
- ↑ Yamamura Y et al OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science. 1991 Apr 26;252(5005):572-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1850553