Slit homolog 3 protein; Slit-3; multiple EGF-like domains protein 5 (SLIT3, KIAA0814, MEGF5, SLIL2, UNQ691/PRO1336)

Function

• may act as molecular guidance cue in cellular migration
  • function may be mediated by interaction with roundabout homolog receptors

Structure

• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 9 EGF-like domains
• contains 1 laminin G-like domain
• contains 20 LRR repeats (leucine-rich repeats)
• contains 4 LRRCT domains
• contains 4 LRRNT domains

Compartment

secreted (putative)

Alternative splicing

named isoforms=3

Expression

predominantly expressed in thyroid

More general terms

• slit homolog protein
• multiple epidermal growth factor like domains (protein)
• leucine-rich repeat-containing protein (LRRC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6586
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6586
• OMIM: https://mirror.omim.org/entry/603745
• UniProt: http://www.uniprot.org/uniprot/O75094.html