sialic acid-binding Ig-like lectin 8; siglec-8; sialoadhesin family member 2; SAF-2; CDw329; CD329 (SIGLEC8, SAF2)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• preferentially binds to alpha-2,3- linked sialic acid
• also binds to alpha-2,6-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

expressed specifically on eosinophils

More general terms

• sialic acid-binding immunoglobulin-like lectin
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27181
• OMIM: https://mirror.omim.org/entry/605639
• UniProt: http://www.uniprot.org/uniprot/Q9NYZ4.html