delta tryptase (mast cell mMCP-7-like, tryptase-3, HmMCP-3-like tryptase 3, TPSD1)

Function

• tryptase is the major neutral protease present in mast cells
• secreted upon the coupled activation-degranulation
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin

Structure

• homotetramer
• belongs to the peptidase S1 family, tryptase subfamily
• contains 1 peptidase S1 domain

Compartment

• secreted
• released from secretory granules upon mast cell activation

Alternative splicing

named isoforms=2

Expression

• expressed in colon, lung, heart & synovial tissue
• may be specific to mast cells

More general terms

• tryptase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BZJ3.html