alpha-tryptase; tryptase-1; tryptase alpha-1 (TPSAB1, TPS1, TPS2, TPSB1)

Function

• tryptase is the major neutral protease present in mast cells & is secreted upon the coupled activation-degranulation response of this cell type
• preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin

Structure

• homotetramer
• belongs to the peptidase S1 family, tryptase subfamily
• contains 1 peptidase S1 domain

Compartment

• secreted
• released from secretory granules upon mast cell activation

Alternative splicing

named isoforms=2

Notes

Removed from UniProt database 12/2010

More general terms

• tryptase

Database

• OMIM: https://mirror.omim.org/entry/191080