neuronal pentraxin-2; NP2; neuronal pentraxin II; NP-II (NPTX2)
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Function
- likely to play role in the modification of cellular properties that underlie long-term plasticity
- binds to agar matrix in a Ca+2-dependent manner (putative)
Cofactor: binds 2 Ca+2 per subunit (putative)
Structure
contains 1 pentraxin domain
Compartment
Expression
- expressed brain, pancreas, liver, heart & skeletal muscle
- highest levels are seen in the testis
Pharmacology
- recombinant pentraxin-2 may slow decline in lung function in patients with idiopathic pulmonary fibrosis[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P47972.html
- ↑ 2.0 2.1 Raghu G, van den Blink B, Hamblin MJ et al Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis. A Randomized Clinical Trial. JAMA. Published online May 20, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29800034 https://jamanetwork.com/journals/jama/fullarticle/2681945
Gibson KF, Kass DJ. Clinical Trials in Idiopathic Pulmonary Fibrosis in the "Posttreatment Era". JAMA. Published online May 20, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29800063 https://jamanetwork.com/journals/jama/fullarticle/2681942