desmoglein-4

Function

• component of intercellular desmosome junctions
• interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion
• transition from proliferation to differentiation in hair follicle keratinocytes

Compartment

membrane

Expression

• expressed in skin, testis, prostate > salivary gland, scalp follicles (inner rooth sheath, matrix, precortex)

Pathology

• defects in DSG4 are the cause localized autosomal hypotrichosis
• DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris

More general terms

• desmoglein (desmosomal glycoprotein)

Additional terms

• localized autosomal hypotrichosis
• pemphigus vulgaris

Database

• OMIM: https://mirror.omim.org/entry/607892
• OMIM: https://mirror.omim.org/entry/607903
• UniProt: http://www.uniprot.org/uniprot/Q86SJ6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=147409