desmoglein-3; 130 kD pemphigus vulgaris antigen; PVA (DSG3, CDHF6)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 4 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)
• cell junction, desmosome

Expression

• epidermis, tongue, tonsil, esophagus including carcinomas

Pathology

• autoantibodies against desmoglein 3 (DSG3) are found in pemphigus vulgaris

More general terms

• desmoglein (desmosomal glycoprotein)

Additional terms

• pemphigus vulgaris

Database

• UniProt: http://www.uniprot.org/uniprot/P32926.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1830
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1830
• OMIM: https://mirror.omim.org/entry/169615