arylsulfatase-B (ARSB, chondro-4-sulfatase, N-acetylgalactosamine-4-sulfatase)

Function

• hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate & dermatan sulfate
• degrades leukotrienes C & D (SRS-A)?

Cofactor: binds 1 Ca+2 per subunit

Structure

• monomer
• belongs to the sulfatase family

Compartment

Lysosome

Expression

produced by eosinophils?

Pathology

• defects in ARSB are the cause of mucopolysaccharidosis-6
• arylsulfatase B activity is defective in multiple sulfatase deficiency

Laboratory

• N-acetylgalactosamine-4-sulfatase in fibroblasts
• N-acetylgalactosamine-4-sulfatase in leukocytes
• N-acetylgalactosamine-4-sulfatase in amniotic fluid
• N-acetylgalactosamine-4-sulfatase in dried blood spot
• N-acetylgalactosamine-4-sulfatase in serum
• N-acetylgalactosamine-4-sulfatase in urine
• N-acetylgalactosamine-4-sulfatase in tissue

More general terms

• arylsulfatase
• lysosomal hydrolase

Database

• UniProt: http://www.uniprot.org/uniprot/P15848.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:411
• OMIM: https://mirror.omim.org/entry/253200
• OMIM: https://mirror.omim.org/entry/272200
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=411