glycoprotein hormone beta 5 (thyrostimulin beta subunit, GPHB5, GPB5, ZLUT1)

Function

• stimulates the thyroid
• binds & activates THSR, leading to increased cAMP production
• heterodimer with GPHA2

Structure

• N-glycosylated
• belongs to the glycoprotein hormones subunit beta family

Compartment

secreted

Expression

• highly expressed in brain & at low levels in pituitary
• also found in retina, testis & skin
• not expressed in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid or adrenal gland
• in pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs

More general terms

• glycoprotein hormone-beta chain

Component of

• thyrostimulin

Database

• UniProt: http://www.uniprot.org/uniprot/Q86YW7.html