limbic system-associated membrane protein (LSAMP, LAMP)

Function

• mediates selective neuronal growth & axon targeting
• role in guidance of developing axons & remodeling of mature circuits in the limbic system
• essential for growth of hyppocampal mossy fiber projection Strucure:
• belongs to the immunoglobulin superfamily, IgLON family
• contains 3 Ig-like C2-type domains (immunoglobulin-like)

Compartment

cell membrane, GPI-anchor

Expression

• expressed on limbic neurons & fiber tracts, single layers of the superior colliculus, spinal cord & cerebellum

More general terms

• glypiated protein
• immunoglobulin superfamily protein

Database

• OMIM: https://mirror.omim.org/entry/603241
• UniProt: http://www.uniprot.org/uniprot/Q13449.html