alkaline phosphatase, placental type 1 (regan isozyme, ALPP, PLAP)

Function

• alkaline phosphatase

phosphate monoester + H2O <--> an alcohol + phosphate

Cofactor:

• binds 1 Mg+2 (putative) binds 2 Zn+2 (putative)

Structure

• homodimer
• belongs to the alkaline phosphatase family

Compartment

• cell membrane, lipid-anchor, GPI-anchor

Polymorphism

• placental ALP is highly polymorphic
• there are at least three common alleles

More general terms

• alkaline phosphatase (placental)
• glypiated protein

Database

• UniProt: http://www.uniprot.org/uniprot/P05187.html
• OMIM: https://mirror.omim.org/entry/171800
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=250