interphotoreceptor matrix proteoglycan 1 (interphotoreceptor matrix proteoglycan of 150 kD, IPM-150, sialoprotein associated with cones & rods, IMPG1, IPM150, SPACR)

Function

• interacts with hyaluronan to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (putative)

Structure

1 N-terminus is blocked

• highly glycosylated (N- & O-linked carbohydrates & sialic acid)
• contains 2 SEA domains

Compartment

extacellular matrix (interphotoreceptor matrix of retina)

Expression

• expressed in retina
• specifically expressed by cone & rod photoreceptor cells
• localizes to cone & rod photoreceptor cells surrounding the interphotoreceptor matrix of the retina

More general terms

• matrix protein
• sialoglycoprotein

Database

• OMIM: https://mirror.omim.org/entry/602870
• UniProt: http://www.uniprot.org/uniprot/Q17R60.html