troponin I, slow skeletal muscle; troponin I, slow-twitch isoform (TNNI1)

Function

• troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity
• binds to actin & tropomyosin

Structure

belongs to the troponin I family

Expression

• highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle)
• expressed in C2 muscle cell myoblasts & myotubes

More general terms

• troponin-I

Additional terms

• troponin

Database

• UniProt: http://www.uniprot.org/uniprot/P19237.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7135
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7135
• OMIM: https://mirror.omim.org/entry/191042