Metallothionein-3; MT-3; Metallothionein-III; MT-III; growth inhibitory factor; GIFB; GIF (MT3)

Function

• binds heavy metals
• inhibits survival & neurite formation of cortical neurons in vitro

Structure

• belongs to the metallothionein superfamily, type 1 family
• contains 3 Zn+2 & 3 Cu+1/Cu+2 per polypeptide chain & only a negligible amount of cadmium

Expression

• abundant in a subset of astrocytes in the normal human brain

Pathology

expression reduced in Alzheimer's disease

More general terms

• metallothionein

Database

• UniProt: http://www.uniprot.org/uniprot/P25713.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4504
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4504
• OMIM: https://mirror.omim.org/entry/139255