Metallothionein-2; MT-2; Metallothionein-II; MT-II; Metallothionein-2A (MT2A CES1 MT2)

Function

• binds Zn+2

Structure

• belongs to the metallothionein superfamily, type 1 family
• metallothioneins have a high content of Cys that bind various heavy metals
• class 1 metallothioneins contain 2 metal-binding domains:
  • 4 divalent ions are chelated within cluster A of the alpha domain & are coordinated via cysteinyl thiolate bridges to 11 Cys ligands
  • cluster B, the corresponding region within the beta domain, can ligate 3 divalent ions to 9 Cys

Expression

• transcriptionally regulated by both heavy metals & glucocorticoids

More general terms

• metallothionein

Database

• UniProt: http://www.uniprot.org/uniprot/P02795.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4502
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4502
• OMIM: https://mirror.omim.org/entry/156360