carbonic anhydrase-9 (membrane antigen MN, P54/58N, renal cell carcinoma-associated antigen G250, RCC-associated antigen G250, pMW1, CA9, G250, MNCA9)

Function

• reversible hydration of carbon dioxide
• may be involved in the control of cell proliferation & transformation

H2CO3 <--> CO2 + H2O

Cofactor: Zn+2 (putative)

Structure

• forms oligomers linked by disulfide bonds
• N-glycosylated
• belongs to the alpha-carbonic anhydrase family

Compartment

• nucleus, nucleolus cell membrane
• cell projection, microvillus membrane
• found on the surface microvilli & in the nucleus, particularly in nucleolus

Expression

• expressed primarily in carcinoma cells lines
• expression is restricted to very few normal tissues
• most abundant expression is found in the epithelial cells of gastric mucosa

Pathology

• appears to be a novel specific biomarker for a cervical neoplasia

More general terms

• carbonic anhydrase (dehydratase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:768
• OMIM: https://mirror.omim.org/entry/603179
• UniProt: http://www.uniprot.org/uniprot/Q16790.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=768