pappalysin-2 (pregnancy-associated plasma protein-A2, PAPP-A2, regnancy-associated plasma protein-E1, PAPP-E, PAPPA2, PLAC3)

Function

• metalloproteinase which specifically cleaves IGFBP-5
• limited proteolysis toward IGFBP-3
• cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5
• binds 1 Zn+2 per subunit

Structure

• monomer
• belongs to the peptidase M43B family.
• contains 5 Sushi domains (CCP/SCR)

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed abundantly in placenta, non-pregnant mammary gland with low expression in the kidney, fetal brain, pancreas

More general terms

• metalloprotease

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BXP8.html