astacin-like metalloendopeptidase (oocyte astacin, ovastacin, ASTL)

Function

• peptidase

Inhibition:

• inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94)
• inhibited by EDTA.

Kinetic parameters:

• Optimum pH is 7.5

Expression

not expressed in normal tissues

Pathology

• expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, some ovarian carcinomas

More general terms

• metalloprotease

Database

• OMIM: https://mirror.omim.org/entry/608860
• UniProt: http://www.uniprot.org/uniprot/Q6HA08.html