cysteine & glycine-rich protein 2; LIM domain only protein 5; LMO-5; smooth muscle cell LIM protein; SmLIM (CSRP2, LMO5, SMLIM)

Function

• drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation & dedifferentiation
• seems to play a role in the development of the embryonic vascular system
• interacts with CSRP2BP; the LIM domain 1 is necessary & sufficient for this interaction
• interacts with GLRX3

Structure

• contains 2 LIM Zn+2-binding domains

Compartment

• nucleus (putative)

Expression

• highly expressed in the aorta
• lesser if any expression in heart & skeletal muscle

More general terms

• LIM domain protein
• nuclear protein

Additional terms

• Cysteine-rich protein 2; CRP-2; protein ESP1 (CRIP2, CRP2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1466
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1466
• OMIM: https://mirror.omim.org/entry/601871
• UniProt: http://www.uniprot.org/uniprot/Q16527.html