rhombotin-1; LIM domain only protein 1; cysteine-rich protein TTG-1; T-cell translocation protein 1 (LMO1, RBTN1, RHOM1, TTG1)

Function

• may be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors

Structure

contains 2 LIM Zn+2-binding domains

Compartment

nucleus (putative)

Expression

• expressed mainly in the central nervous system
• low level of expression in other tissues including thymus

Pathology

• chromosomal translocation t(11;14)(p15;q11) involving LMO1 with TCRD may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL)

More general terms

• LIM domain protein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/P25800.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4004
• OMIM: https://mirror.omim.org/entry/186921