helicase with zinc finger domain; down-regulated in human cancers protein (HELZ, DRHC, KIAA0054)

Function

• helicase
• role in RNA metabolism in multiple tissues & organs within the developing embryo
• interacts with SMYD2 (putative
• interacts with POLR2A
• interacts with SMYD3
  • interaction may bridge SMYD3 & RNA polymerase 2

Structure

• belongs to the DNA2/NAM7 helicase family
• contains 1 C3H1-type Zn+2 finger

Compartment

nucleus (probable)

Expression

• expressed predominantly in thymus & brain
• expression is down-regulated in 28 of 95 tested cancer cell lines

More general terms

• helicase (DNA unwinding protein, DNA untwisting protein)
• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606699
• UniProt: http://www.uniprot.org/uniprot/P42694.html