protein arginine N-methyltransferase 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 (PRMT3, HRMT1L3)

Function

• protein arginine N-methyltransferase
• methylates (mono & asymmetric dimethylation) guanidino nitrogens of Arg in some proteins
• may exist as a monomer or homodimer (putative)

Inhibition:

• inhibited by N-ethylmaleimide & high concentrations of Zn+2 chloride (putative)

Structure

• the Zn+2-finger is responsible for substrate specificity
• belongs to the protein arginine N-methyltransferase family
• contains 1 C2H2-type Zn+2 finger

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• protein arginine N-methyltransferase (PRMT)
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10196
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10196
• OMIM: https://mirror.omim.org/entry/603190
• UniProt: http://www.uniprot.org/uniprot/O60678.html