acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-ketoacyl CoA thiolase, peroxisomal 3-oxoacyl-Coenzyme A thiolase, beta-ketothiolase, thiolase-3, ACAA1, ACAA, PTHIO)

Function

• lipid metabolism, fatty acid metabolism

acyl-CoA + acetyl-CoA <--> CoA + 3-oxoacyl-CoA

Structure

• homodimer
• belongs to the thiolase family

Compartment

peroxisome

Expression

• peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system

More general terms

• 3-ketoacyl CoA thiolase (beta-ketothiolase, ACAA)

Database

• UniProt: http://www.uniprot.org/uniprot/P09110.html
• OMIM: https://mirror.omim.org/entry/604054
• OMIM: https://mirror.omim.org/entry/261515
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30