pyruvate dehydrogenase [lipoamide] kinase, isoenzyme 4 (PDK4)

Function

• inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism

Structure

• belongs to the PDK/BCKDK protein kinase family
• contains 1 histidine kinase domain

Compartment

mitochondrial matrix

Expression

• ubiquitous
• highest levels of expression in heart & skeletal muscle

More general terms

• pyruvate dehydrogenase kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5166
• OMIM: https://mirror.omim.org/entry/602527
• UniProt: http://www.uniprot.org/uniprot/Q16654.html