[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN (BCKDK)

Function

• catalyzes phosphorylation & inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine & isoleucine catabolic pathways
• dehydrogenase (acetyl-transferring)] phosphate
• autophosphorylated (putative)

ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate

Structure

• monomer (putative)
• belongs to the PDK/BCKDK protein kinase family
• contains 1 histidine kinase domain

Compartment

mitochondrial matrix

Expression

ubiquitous

More general terms

• kinase or ATP-phosphotransferase
• phosphoprotein
• mitochondrial protein

Additional terms

• branched-chain ketoacid dehydrogenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10295
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10295
• UniProt: http://www.uniprot.org/uniprot/O14874.html