pyruvate dehydrogenase [lipoamide] kinase, isoenzyme 3 (PDK3)
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Function
- inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism
Structure
- belongs to the PDK/BCKDK protein kinase family
- contains 1 histidine kinase domain
Compartment
Expression
- found almost exclusively in heart & skeletal muscle