pyruvate dehydrogenase [lipoamide] kinase, isoenzyme 2 (PDK2)

Function

• inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism

Structure

• belongs to the PDK/BCKDK protein kinase family
• contains 1 histidine kinase domain

Compartment

mitochondrial matrix

Expression

• expressed in many tissues
• expressed in heart & skeletal muscle > brain, kidney, pancreas & liver > placenta & lung

More general terms

• pyruvate dehydrogenase kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5164
• OMIM: https://mirror.omim.org/entry/602525
• UniProt: http://www.uniprot.org/uniprot/Q15119.html