cell division cycle-associated protein 4; hematopoietic progenitor protein (CDCA4, HEPP)

Function

• may participate in regulation of cell proliferation through the E2F/RB pathway
• may be involved in molecular regulation of
  • hematopoietic stem cells
  • progenitor cell lineage commitment
  • differentiation

Structure

contains 1 SERTA domain

Compartment

nucleus

Expression

• highest expression in the pancreas, thymus, testis, spleen, liver, placenta & leukocytes.
• lesser expression in lung, kidney, prostate, ovary, small intestine & colon
• hardly detectable, if at all, in the brain, skeletal muscle & heart
• induced by E2F1

More general terms

• cell division cycle-associated protein 4 (CDCA)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55038
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55038
• OMIM: https://mirror.omim.org/entry/612270
• UniProt: http://www.uniprot.org/uniprot/Q9BXL8.html